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why/how do you develop a reaction or allergy to something?

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I had morphine for the first two caesarian births of my children but on the third developed an extreme sensitivity to morphine and have not been able to use it since over 9 years later the strongest pain medication I can have is panadeine forte and nurofen forte my boyfriend had the same problem with iodine suddenly developing a reaction to it after nearly 20 years of no problems
Does anyone know why this occurs? does the body get rid of this or do these things build up in the body like antibiotics