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How to clean my computer system of this virus?

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Okay I run avast anti virus which is updated regulary - but for some reason it slipped up and I got some worms and trojans and because of this when I double click either hard drive in My Computer it used to open it in a brand new window but now it opens up one of those 'what program do you want to use to open this program" dialogues...

anyone know any applications I could use to clean my system and undo any errors that this virus has caused? I still don't even know if I've managed to get rid of them all and I cannot afford to reformat my computer at this point.

HELP!!!