My Mom is Manic Depressive and talks to me with distain and disgust

First and foremost you need to acknowledge that this is not your fault. It is easy for those who are close to depressed people to assume responsibility for their symptoms and to take them personally. This is your mother’s problem, and all that you can do at this stage is try to help her out of it. I would talk to a social worker or a psychologist first so that you know what options are available to you (i.e., in terms of intervention). Anti-depressants are not always effective, and I view many of them as ‘mood-stabilisers’ rather than ‘mood-enhancers’. If she is constantly experiencing low mood, then I find it hard to believe that these dr*gs are going to be effective (more likely they’ll be counterproductive), but I suppose this depends on what kinds of medications she has been prescribed..

Talk to your mother and try to get her to seek help (e.g., therapy). If your mother is ‘manic-depressive’ then that must mean that she also experiences periods of euphoria / hypomania. Hypomania often involves risk-taking / dangerous behaviours and so the possibility of self-harm must also be considered. If she continues to isolate herself and merely preserve her low mood, then I would suggest that you speak to a social worker or a psychologist about intervention. You can never be too cautious with things like this.

i am in the same situation in the same house same person type. best thing to do it get out because people like this are unreasonable and only believe what they want.